2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N3906
    Fraxamoside 326594-34-7 98%
    Fraxamoside is a competitive xanthine oxidase inhibitor with an IC50 of 16.1 μM and a Ki of 0.9 μM.
    Fraxamoside
  • HY-N3997
    Nostosin G 3033950-58-9 98%
    Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC50 value of 0.1 μM.
    Nostosin G
  • HY-N4143
    Cyanidin 3-arabinoside 27214-72-8 98%
    Cyanidin 3-arabinoside is a selective and reversible protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes.
    Cyanidin 3-arabinoside
  • HY-N4174
    Raddeanoside 20 335354-79-5 98%
    Raddeanoside 20 is a triterpenoid isolated from the rhizome of Anemone raddeana. Raddeanoside 20 can suppresse superoxide generation.
    Raddeanoside 20
  • HY-N4313
    Eriosematin 168010-17-1 98%
    Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property.
    Eriosematin
  • HY-N4330
    Rivulariapeptolides 1155 98%
    Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively.
    Rivulariapeptolides 1155
  • HY-N5089
    (+)-Balanophonin 215319-47-4 98%
    (+)-Balanophonin is a phenolic compound that could be isolated from Passiflora edulis. (+)-Balanophonin possesses anti-oxidant, anticholinesterase, anti-inflammatory, anticancer, and antineurodegenerative activities.
    (+)-Balanophonin
  • HY-N5095
    Eupteleasaponin I 290809-29-9 98%
    Eupteleasaponin I is a component of Euptelea polyandra, may has gastroprotective activity.
    Eupteleasaponin I
  • HY-N6575
    7β-Hydroxybufalin 20143-97-9 98%
    7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase.
    7β-Hydroxybufalin
  • HY-N6720
    T-2 Triol 34114-98-2 98%
    T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin. T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively.
    T-2 Triol
  • HY-N6828
    Monocrotaline N-Oxide 35337-98-5 98.90%
    Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo.
    Monocrotaline N-Oxide
  • HY-N6849
    InteriotherinA 181701-06-4
    Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent.
    InteriotherinA
  • HY-N6883
    6-Methoxytricin 76015-42-4 98%
    6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC50 values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent.
    6-Methoxytricin
  • HY-N6903
    Geoside 585-90-0 98%
    Geoside (Gein) is a natural compound isolated from stevia rebaudiana.
    Geoside
  • HY-N6910
    Pseudolaric Acid C2 82508-35-8 99.17%
    Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats.
    Pseudolaric Acid C2
  • HY-N6918
    Steviol-​19-​O-​glucoside 1185737-16-9 98%
    Steviol-​19-​O-​glucoside is a metabolite of steviol in the steviol glycosides biosynthesis pathway in Stevia rebuadiana.
    Steviol-​19-​O-​glucoside
  • HY-N6930
    Shikonofuran A 85022-66-8 98%
    Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
    Shikonofuran A
  • HY-N6957
    8-Keto-berberine 81397-08-2 98%
    8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine.
    8-Keto-berberine
  • HY-N6989
    Isoglycycoumarin 117038-82-1 98%
    Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6).
    Isoglycycoumarin
  • HY-N6991
    11-Deoxymogroside IIIE 1793003-47-0 99.97%
    11-Deoxymogroside IIIE is a natural product isolated from Siraitia grosvenorii.
    11-Deoxymogroside IIIE
Cat. No. Product Name / Synonyms Application Reactivity